Dr Dingle's Blog / triclosan

Dr Peter Dingle’s South West WA Wellness Tour

Dr Peter Dingle’s South West WA Wellness Tour

Hope you can make it to one of our talks

Toxic Overload

October 16, 7.00 pm

Harvey

http://tix.yt/toxicoverloadharvey

 

Toxic Overload

October 17, 7.00 pm

Dalyellup

http://tix.yt/toxicoverloaddalyellup

 

Your Gut Health, Microbiome and Probiotics

October 18 2017

Bunbury turf club

Blair Street Bunbury 6230 Australia

7.00-9.00 PM each night

http://tix.yt/gutmicrobiomeprobioticsbunbury

 

7 Steps To Permanent Weight Loss 

October 19 2017

Bunbury turf club

Blair Street Bunbury 6230 Australia

7.00-9.00 PM each night

http://tix.yt/weightlossbunbury

 

Toxic Overload

October 20, 9.30 am

Leshenault

http://tix.yt/toxicoverloadleshanaultam

 

Toxic Overload

October 20, 7.00 pm

Leshenault

http://tix.yt/toxicoverloadleshanaultpm

 

 

Toxic Overload

October 23, 7.00-9.00 pm

Dunsborough

http://tix.yt/toxicoverloaddunsborougham

 

 

Toxic Overload

October 24, 9.30 -11.30 am

Dunsborough

http://tix.yt/toxicoverloaddunsboroughpm

 

 

Your Gut Health, Microbiome and Probiotics

October 24, 2017

Dunsborough

St George Community Care 48 Gibney Street

 http://tix.yt/gut-healthprobioticsdunsborough

 

Albany

Dog Rock Motel seminar room

303 Middleton Road Mount Clarence 6330

7.00-9.00 PM each night

 

October 26, 2017

Your Gut Health, Microbiome and Probiotics

http://tix.yt/gutmicrobiomeprobioticsalbany

 

October 27 2017

Dangerous Beauty. The toxic truth about cosmetics and personal care products

http://tix.yt/dangerousbeautyalbany

 

October 28 2017

The 7 steps to permanent weight loss

http://tix.yt/weightlossalbany

 

Toxic Overload

We are now surrounded by long list of modern day toxic chemicals in our homes and the personal care products that are impacting on our health.  These poisons and potions are playing their role in making us sick and are linked with the increase in disease like breast cancer, hormone imbalances, thyroid problems and even infertility. Even at “so called” normal levels these chemicals contribute to diseases such as fatigue, depression, stress and anxiety and are linked with diabetes, cardio vascular disease, cancer, estrogen and hormone havoc and weight gain.

This presentation will change your attitudes to many things around you and your home, how you clean and what you put on your skin and empower you to make some simple changes to improve your health. We’ll show you that with a few simple modifications you can easily improve the health status of your home, your wellbeing and that of your family.

 

Gut Health, Microbiome and Probiotics.

Probiotics and a healthy microbiome in our digestive tract is now recognised as one of the most critical conditions for our health and wellbeing. While it is obvious when it comes to many digestive disorders recent research has shown it can be involved in virtually every form of chronic illness. A study in 2016 for example confirmed that up to 50% of Parkinson’s disease can be related to an unhealthy gut microbiome. While many skin conditions like eczema, psoriasis and even acne as well as Alzheimer’s, MS, allergies, diabetes type 1 and 2 and high blood pressure are all related to a healthy gut. Even weight gain and weight loss is influenced by your gut microbiome. Both directly and indirectly a healthy gut can determine how healthy you are and even how much weight you put on. However, a healthy gut is determined by many more factors than just supplementing with probiotics or eating yoghurt.

In this one night presentation you will learn about the importance of gut health as well as what steps you can take to improve. This night is a must to see.

 

7 Steps To Permanent Weight Loss 

Diets, counting calories and low fat foods don’t work because they are working against your genes. These diets are going against millions of years of evolution. Studies on these types of diets show impaired mental performance, poor immediate memory and slower reaction times, they lose more muscle and develop metabolic and immune system disorders. Even more disturbing people on these diets lose muscle, end up putting on more weight and die younger.

The reason is that these Diets focus on the wrong thing. They ignore the genetic, biochemical and nutritional needs of your body so they can never succeed.

Learn the secrets of weight loss and the language of talking to your genes. Learn to retune your genes to lose extra kilos of weight without dieting.

Dr Dingle will show you by focusing on nutrient dense foods, supplementation, the right protein foods, probiotics and eliminating toxins you can unlock your genes for weight loss and wellbeing without dieting and exercise.

 

Dangerous Beauty. The toxic truth about cosmetics and personal care products

(Albany Only)

The personal care and cosmetic products you use directly influence the health of your family. These products impact their hormone levels and thyroid function and are linked with weight gain. These chemicals are linked with Estrogen overload and hormone imbalances, Breast and prostate cancer, Thyroid dysfunction and hypothyroidism, Impaired immune system, Skin ageing, infertility and testosterone in males and so much more.

Most Personal care products contain parabens, phthalates, solvents, mineral oils and other hormone disrupting chemicals and you won’t even know it because they may be a “secret ingredient” or even formaldehyde hidden under another name.

We now know that many of these toxic chemicals pass through the skin and into the blood where they can accumulate and cause damage and can pass into the placenta and accumulate in breast tissue.

Every application increases the risk and exposure and of greatest concern is that it is young women and girls who are most exposed to these toxins. But no one is exempt. Even girls of 5 and 6 are showing up with high concentrations of these toxins.

The good news is that by learning a little bit and avoiding these chemicals and making a few simple changes to your lives you can make a big difference to the health of your family. Your choices today have the power to affect fertility, breast cancer and weight gain even for the next few generations.

At this presentation you will find out what you can do to protect your family health, what to avoid and what is ok.

Dr Peter Dingle PhD

Exploding old belief systems, Dr Dingle dispels myths and confusion around health and how to create long lasting wellbeing. He puts the real facts at your fingertips, then provides you with personalised options to ensure your choices get you the best out of your future.

Nobody knows wellness like Dr Peter Dingle, Australia’s most engaging and innovative thought leader on the topics of health, wellness and weight loss who presents cutting-edge science in a bold, courageous, humourous and straight-shooting manner.

Dr Dingle is Australia's most popular and qualified professional speaker. He holds 2 Degrees in Science and a PhD, 21 years as an academic at Murdoch University and written 15 books on health and wellness.

Dr Dingle has a unique ability to entertain, educate and involve simultaneously. A natural entertainer, Dr D transports delighted audiences on a journey of truth and laughter that will empower them to optimize energy and health, find better life balance and their health

Dr Peter Dingle is known both in Australia and around the world as one of the most impactful and engaging thought leaders in the Health and Wellness Movement.  Over the last 30 Years he has helped hundreds of thousands of people better their lives by cutting through medical and health myths to give the real facts on evidence-based wellness.

 

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Sickness from the smelling industry and the health effects of fragrance compounds.

Sickness from the smelling industry and the health effects of fragrance compounds.

In the past few decades, synthetic fragrance compounds have become ubiquitous components of personal care and household cleaning products. Overwhelming consumerism trends have led to the excess usage of these chemicals. It has been observed that this fragrance-laden unhealthy lifestyle runs parallel with the unprecedented rates of diabetes, cancer, neural ailments, teratogenicity, and transgender instances. The link between fragrances as and the health outcomes can remain latent for decades.

The adverse effects of the fragrance constituents as phthalates, paraben, glutaraldehyde, hydroperoxides, oil of turpentine, metals, nitro musks, and essential oils, among others, are being identified. The endocrine-immune-neural axis pathways of these chemicals are being proven. Despite this a majority of the vulnerable populations are unaware and unmotivated to avoid these 'slow poisons'. Possible mechanism for thier action include acidosis, aromatase upregulation, estrogen hyperproduction and inflammation.

Fragrance compounds share structural similarity with carcinogenic environmental hydrocarbons are able to mimic estrogen, the powerful signaling hormone, which underlies the majority of morbidities.

 

source

https://www.ncbi.nlm.nih.gov/pubmed/28478814

 

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200 scientists rally against triclosan in colgate toothpaste and cleaning products.

200 scientists rally against triclosan in colgate toothpaste and cleaning products.

Two hundred scientists any benefits of triclosan and triclocarban—used in some soaps, toothpastes, detergents, paints, carpets—are outweighed by the risk. While other studies and the FDA in the US say there is no benefit from using these ingredients over basic soap and cleaning products.

these two chemicals have been used for years without any definitive proof they’re providing benefits.
The compounds are used in an estimated 2,000 products but are being phased out of some uses. In February the EU banned triclosan in hygiene products. U.S. manufacturers are phasing out triclosan from hand soaps after the Food and Drug Administration banned it last year amid concerns that the compound disrupted the body's hormone systems.
And in Australia they are doing nothing.

However, just as worrying some manufactures of personal care products are simply substituting other antimicrobials for triclosan when they are not even needed.

The Florence Statement on Triclosan and Triclocarban

As scientists, medical doctors, and public health professionals, we are concerned about the continued widespread use of the chlorinated antimicrobials triclosan and triclocarban for the following reasons:

Triclosan and triclocarban are used as antimicrobials, a class of chemicals present in >2,000 products including soaps, toothpastes, detergents, clothing, toys, carpets, plastics, and paints. In personal care products like hand soap, there is no evidence that use of triclosan or triclocarban improves consumer or patient health or prevents disease.
Triclosan and triclocarban used in consumer products end up in the environment and have been detected in a wide variety of matrices worldwide.
Triclosan and triclocarban persist in the environment and are a source of toxic and carcinogenic compounds including dioxins, chloroform, and chlorinated anilines.
Triclosan, triclocarban, and their transformation products and byproducts bioaccumulate in aquatic plants and animals, and triclosan partitions into human blood and breast milk.
Triclosan and triclocarban have detrimental effects on aquatic organisms.
Humans are exposed to triclosan and triclocarban through direct contact with personal care products and from other sources including food, drinking water, and dust. Triclosan has been detected in the urine of a majority of humans tested.
Triclosan and triclocarban are endocrine disruptors and are associated with reproductive and developmental impacts in animal and in vitro studies. Potential implications for human reproduction and development are of concern and merit further study.
Human epidemiology and animal studies suggest triclosan exposure can increase sensitivity to allergens.
Overuse of triclosan may contribute to antibiotic/antimicrobial resistance and may modify the microbiome.
A number of authorities, including the FDA, have restricted the use of triclosan and triclocarban in certain types of soaps. These and other antimicrobial chemicals are generally not restricted from use in other products.

We therefore call on the international community to limit the production and use of triclosan and triclocarban and to question the use of other antimicrobials. We urge scientists, governments, chemical and product manufacturers, purchasing organizations, retailers, and consumers to take the actions recommended below.
Source
https://ehp.niehs.nih.gov/ehp1788/

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Triclosan - Deadly Ingredient

Triclosan - Deadly Ingredient

Triclosan is another one of those chemicals that is finally on its way out even though we have known of its toxic effects for decades. After many decades of scientific scrutiny many companies are now removing TCS. Colgate removed triclosan from its Soft-soap liquid hand soaps and Palmolive antibacterial dish liquid in 2011. Unfortunately, the big companies still deny it is a problem but are phasing it out because of public concerns citing “changing consumer preferences and superior formulations”. Interestingly most of the research now shows it is not even effective in what it does.

Triclosan (TCS) is a biocide used as an antibacterial and antifungal agent in a number of consumer products such as toothpaste, mouthwash, disinfectants, soaps, hair products, skin creams (0.1%), feminine hygiene products, and cosmetics (Fang et al 2010, Dhillon et al Int J Environ Res Public Health. 2015). Personal care products and cosmetics are the major source of exposure and studies on human subjects using TCS-containing cosmetics showed variable but significant amounts of TCS in their body fluids (Allmyr et al 2006, Sandborgh-Englund et al 2006) compared to controls.

Triclosan is also used as a preservative, fungicide, and biocide in household cleaning products and is infused into other household items such as kitchen utensils, cutting boards, kitchen wipes, mop heads, computer equipment, clothing, air filters, flooring, toys, bedding, and trash bags (Fang et al 2010). Research suggests that beyond its use in clinical applications (in hospitals) and toothpaste to prevent gingivitis (Gunsolley, 2006) there is questionable evidence that triclosan provides any extra benefit in other consumer products (Tan et al 2002). In 2001, a national survey detected triclosan and triclocarban in 76% of liquid soaps and 29% of bar soaps (Perenceivich et al 2001) whereas now it is likely to be in less than 10-20% of these products. However, as we have already seen many times, what is on the label is not always what is in the products and it has been detected in conventional dish liquid products at low concentrations, although it was not listed on the product labels.

Because of such widespread use in cosmetics, personal care and cleaning products TCS is one of the more frequently detected and highly concentrated contaminants in aquatic and terrestrial environments particularly in drinking water (Dhillon et al Int J Environ Res Public Health. 2015). Triclosan was among the top seven organic wastewater contaminants found in samples from a network of 139 streams across 30 states by the U.S. Geological Survey (Kolpin et al 2002). Looking at the chemical structure of TCS implies that it may have chemical properties related to many toxic compounds, such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), bisphenol A (BPA) and dioxins (Allmyr Sci Total Environ. 2008).

Use of these products, which typically contain 0.1 to 0.3% of the compound, results in absorption through lining of the gastrointestinal tract and mouth, and through the skin (Bhargava etal Am. J. Infect. Control. 1996; Dann and Hontela J. Appl. Toxicol. 2011)

Given the prevalence of triclosan in the environment, it is not surprising that measurable levels have been detected in just about every person even if you don’t use products with it on the label (Casas et al 2011, Philippat et al 2014). TCS absorption and distribution are rapid in humans and detectable levels have been found in body fluids such as amniotic fluid, blood, breast milk and urine (Allmyr et al. Sci Total Environ. 2006, Philippat et al. Environ Health Perspect. 2013) and TCS was detected in 100% of urine and 51% of cord blood samples in pregnant women in 181 expectant mothers from New York (Pycke et al Environ Sci Technol. 2014). TCS was also found in human tissues such as adipose tissue, brain, liver and nails (Geens et al.2012). The high TCS concentrations in the tissues relative to the environmental concentrations suggests that TCS bio-accumulates and is distributed all through human tissues. Other chemicals such as Propylene glycol, which is commonly found in the same product, has been shown to increase skin absorption of TCS (Fang et al. 2014).

Moreover, TCS has been detected in amniotic fluid, indicating that TCS can enter the fetal environment through the placenta (Philippat et al 2013). Fetal life is considered a particularly vulnerable period for exposure to EDC’s because hormonal disturbances during organ development may introduce irreversible changes (MacLeod et al 2010). Studies on pregnant rats have also reported the greatest bioaccumulation of TCS was observed in the placenta and that the hormone disruption might subsequently affect fetal development and growth (Feng et al. 2016).

In the U S, about two-thirds of 90 girls surveyed, aged 6–8 year olds had detectable TCS in their urine (Wolff et al. 2007). Among some Chinese school children aged 3–24 years old, higher TCS levels in urine were reported among females than their male counterparts. 93 % of those between 18 and 24 years had detectable levels (Li et al. 2013). Interestingly, in one study triclosan concentrations were a factor of 2 higher in Australian serum than in the Swedish plasma samples (Allmyr et al. (2008) most probably due to the discouragement to use triclosan containing products by the Swedish government and the lack of concern from the Australian authorities. Samples collected around Australia were remarkably homogenous with little differences between various groups showing they all appear to have a high exposure.

Breastfeeding infants represents a major route of exposure to TCS. In highly industrialized countries elevated concentrations breast milk are common (Dayan 2007). This is a major concern because of their immature metabolizing pathways of infants makes them particularly vulnerable to the negative impact of TCS. Not to mention they may be relying on just one source of food. Moreover, levels of triclosan in breast milk may be increased by underarm cosmetic use, which presents a direct dermal route of exposure to underlying epithelial tissue (Darbre, Best Pract. Res. Clin. Endocrinol. Metab. 2006) and a study of Swedish women who are users of personal care products containing triclosan had higher concentrations in milk and serum than women who use similar personal care products that presumably contain no triclosan (Allmyr et al. (2006) showing that personal care products containing triclosan were the dominant, but not the only, source of exposure to triclosan.

Health effects

Similar to all the research on the other EDC’s the latest science has shown that even small doses of certain chemicals can significantly affect hormone functions, if they are delivered at the wrong moment. The endocrine-disrupting properties of TCS including its effects on estrogen, testosterone activity and disturbance of thyroid hormone action (Arancibia et al.2009, Crofton et al. 2007; Henry and Fair 2013; Jung et al. 2012; Schiffer et al.2014, Paul et al 2010, Rodriguez and Sanchez 2010, Rotroff et al 2010) has been shown to occur at concentrations typically found in the studies on humans and the environment (Foran et al Mar Environ Res. 2000).

Because of its widespread environmental contamination many studies have been done on aquatic species show the same type of results. In a study on toads TCS exposure not only resulted in delayed growth and development but also caused birth defects in the animals embryos, and the developmental effects of TCS at high concentrations may be associated with disruption of the thyroid (Chai et al Ecotoxicology. 2016). Another study on tadpoles exposed to TCS developed into smaller froglets and had malformed legs (Helbing et al 2006 Aquatic Toxicology). In humans, recent studies have shown an increasing number of potential birth defects. In a study of 520 male newborns, prenatal triclosan exposure was inversely associated with prenatal growth parameters at week 33 and was statistically associated with reduced head circumference at birth (Philippat et al 2014). In another study prenatal TCS exposure was associated with reduced head and abdominal circumference at birth (Harmer Lassen,et al 2014 Environ Health Perspect)

Increasing evidence suggests that triclosan plays a role in cancer development, perhaps through its estrogenicity or ability to inhibit fatty acid synthesis (Dinwiddle et al 2014, Lee et al. 2012), Rodricks et al. 2010; Winitthana et al.2014; Wu et al.2014; Yueh et al.2014). Including breast cancer (Lu and Archer 2005, Lee et al Chem. Res. Toxicol. 2014) and liver tumours. Numerous studies have now investigated TCS’s estrogenic action in cultured cancer cells, animals and human and have shown estrogen activity. The results of these studies suggest that TCS affects cancer cell proliferation, particularly in the presence of estradiol. In male rats, TCS exposure led to decreases in serum testosterone, sperm production and male reproductive gland weight (Kumar et al Reprod Toxicol. 2009) as well as reduced ability to reproduce.

During the last decade, there has been a remarkable and unexplained increase in the prevalence of asthma. Some have hypothesized that widespread use of antimicrobial ingredients such as TCS may be a contributing factor. This concept is based on the hygiene hypothesis, which proposes that lack of pathogen exposure during development can alter the usual development of the immune system by eliminating or changing the commensal microbiota. But also for the potential of these antimicrobial products to alter the gut microbiome which is so important for the development of the immune system.

There are also increasing evidence of TCS-induced allergic reactions in humans. Dermatitis following prolonged use of TCS-containing hand washes (Wong and Beck 2001) or when further exposed to sunlight after use (Schena et al. 2008) have been recorded. Similarly, blisters were known to have erupted in the mouth and on the lips of human subjects following prolonged use of TCS-containing toothpaste (Robertshaw and Leppard 2007). A study conducted between 2003 and 2006 found a positive association between elevated urinary TCS levels and allergy or hay fever diagnosis, and concluded that TCS may negatively affect the immune system (Clayton et al 2011). A more recent study using data from 860 children obtained from the 2005–2006 National Health and Nutrition Examination Survey found levels of urinary TCS was positively associated with allergies and food sensitization (Savage et al 2012). Another study also found that skin exposure to TCS in the presence of an allergen can augment the allergic response to that allergen (Anderson et al Toxicol Sci 2013).

TCS is known to have a negative impact on β cells in the pancreas which impacts on insulin synthesis and function and ultimately contributing to diabetes (Pi et al.2007). Its negative effect on the power house of the cells, the mitochondria may also be a contributing factor to diabetes (Ajao et al 2015).

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Reducing toxic chemical exposure reduces the risk of diabetes

Reducing toxic chemical exposure reduces the risk of diabetes

New research suggests that a 25% reduction in exposure to just 4 chemicals commonly found in the home would reduce diabetes cases by around 13% which could save billions of dollars in annual health costs.
 
Increasing evidence suggests that synthetic chemicals commonly found in the environment contribute to metabolic disorders, especially obesity and diabetes. Previous publications have associated prevalent diabetes with polychlorinated biphenyls (PCBs), persistent chlorinated pesticides, phthalates and perfluoroalkyl substances (PFASs). Separate studies found similar connections between diabetes and exposure to DDT, PCBs and perfluoroalkyl.

In this study of 1,016 participants they found significant connections between the four chemicals investigated and a number of different diseases and found reduced exposure to all four chemicals would lead to a likely reduction 13% in diabetes cases. This study confirms substantial contribution, especially of mixtures of endocrine-disrupting chemicals, to adult type 2 diabetes, and large annual costs of medical care. A previous reported a significant positive relationship between phthalates in the blood and lowered insulin secretion, increased insulin resistance or both.
    
While this study supports efforts to reduce chemical exposures to reduce the burden and costs of diabetes there are many other disease states including cardiovascular disease and cancer that would also likely be reduced.

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Toxic chemicals cause weight gain

Toxic chemicals cause weight gain

Exposure to “obesogenic” chemicals has an important role in the obesity and diabetes pandemic. Studies dating back to the 1970s have shown that low-dose chemical exposures were associated with weight gain in experimental animals. Since then, a growing number of studies show links between toxins and weight gain, obesity and diabetes. Known or suspected culprits behind negative epigenetic changes include toxins such as heavy metals, pesticides, plastic compounds including BPA, diesel exhaust, tobacco smoke, polycyclic aromatic hydrocarbons, hormones, radioactivity, viruses, bacteria and endocrine disrupting chemicals.

The main role of fat cells is to store energy and release it when needed. Scientists now know that fat tissue acts as an endocrine (hormone) organ, releasing hormones related to appetite and metabolism. Research to date suggests that different obesogenic compounds may have different mechanisms of action, some affecting the number of fat cells, others the size of fat cells, and still others the hormones that influence appetite, satiety, food preferences, and energy metabolism. Another mechanism through which these chemical obesogens can contribute to weight gain is through their impact on the gut microbiome, linking gut ecology and environmental chemicals to obesity and diabetes.

BPA, or bisphenol-A, a chemical found in everything from plastic bottles to metal food containers, may be partly to blame for our excess weight. BPA has been shown to alter the body’s metabolism, increasing weight gain and making it difficult to lose weight. In a study of 1,326 children, girls between ages 9 and 12 with high BPA levels had double the risk of being obese than girls with low BPA levels, validating previous animal and human studies. The chemical can alter the body’s metabolism and make it harder to lose weight. Girls with high levels of BPA, two micrograms per litre or more, were twice as likely to be obese as girls with lower levels of BPA in the same age group. Girls with very high levels of BPA, more than 10 micrograms per litre, were five times more likely to be obese, the study showed. In animal experiments, a mother’s exposure to BPA is producing the same outcomes that we see in humans born light at birth: an increase in abdominal fat and glucose intolerance. BPA affected rodent fat cells at very low doses, 1,000 times below the dose that regulatory agencies presume causes no effect in humans.

A growing body of evidence shows that the use of certain pesticides may also be associated with weight gain and diabetes risk. In animal experiments, mice fed high-fat diets gained about 30% more weight and had higher blood sugar than other mice eating the same high-fat diets when they also ingested doses of a brominated flame retardant, hexabromocyclododecane (HBCD), which is used in building materials and insulation. Perfluorooctanoic acid (PFOA) is a ubiquitous chemical, used in non-stick cookware, Gore-Tex™ waterproof clothing, Scotchgard™ stain repellent on carpeting and mattresses and is a potential endocrine disruptor. Researchers gave pregnant mice PFOA during pregnancy and when the offspring reached adulthood, they became obese, reaching significantly higher weight levels than controls. Phthalates are plasticizers that have been related to obesity in humans and occur in many PVC items as well as in scented items such as air fresheners, laundry products, and personal care products, and many plastics.
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Environmental Estrogens in cosmetics and personal care products. Breast Cancer and Toxicity

Environmental Estrogens in cosmetics and personal care products.  Breast Cancer and Toxicity

It is estimated that in the world today, there are at least 120,000 synthetic chemicals, or xenobiotics registered for commercial use and around 1,000 new chemicals are formulated each year. While many have been proven to be highly toxic and carcinogenic, little is known about the chronic effects particularly their potential to alter, or disrupt the function(s) of the endocrine system and our hormones. These synthetic chemicals are known as 'environmental estrogens', estrogen mimics, or xenoestrogens and have been found to affect hormonal functions by 'mimicking' the function of naturally occurring estrogen in the body.

Estrogens are a group of naturally occurring hormones present in both male testes and female ovaries, with females producing a considerably higher amount. They are particularly influential during puberty, menstruation and pregnancy; however they also assist in regulating the growth of bones, skin, liver and organs of the cardiovascular system. Estrogens, like all hormones, act as chemical signals and are important in helping cells in various organs to sense and respond to changing physiological conditions; therefore the right balance of hormones is critical in order to carry out the functions required of a healthy, strong body. Estrogen binds to a protein, or estrogen receptor, and the estrogen receptor complex can then bind to specific genes and by this, alter the way they are expressed, resulting in a change in cell programming 1.

Environmental estrogens, are now present in everyday products such as polycarbonate plastics, food packaging and cans. However the greatest source for many people is through cosmetics and personal care products and include chemicals such as triclosan, cyclosiloxanes, parabens and phthalates which are often left on the skin to absorb and accumulate 2. Women are disproportionately exposed to many environmental estrogens like paraben and phthalates because they use more personal care products on average than men 3 and teenage girls tend to use even more products than women, averaging 17 different products per day, compared with 12 for women 4.

Since the 1980's, there has been a growing amount of research toward the potential interaction between these environmental estrogens and wild animals, with a number of reports detailing the emergence of 'feminised wildlife’ around the world, and a range of adverse effects in humans including decreased sperm count, increased cases of testicular cancer and testicular abnormalities, increased breast cancer in men and women and premature or precocious puberty. Other adverse health include headache, migraine, depression, gastrointestinal disturbances, insomnia, mastopathia, changes in vaginal bleeding 5. More chronic symptoms affect the cardiovascular system, the skin (itching, rash, abnormal pigmentation), the gallbladder, and tumours, particularly of the breast but also uterus, cervix, vagina and liver 5.

One of the most troubling is their association with breast cancer 6,7,8. Breast cancer is the major cancer affecting women in the Western world 9 and one of the most disturbing and well documented current trends is the alarming increase in breast cancer incidence over the past few decades. Fifty years ago the risk rate was one woman in 20; today it is one in 8 and approximately two-thirds of breast tumors are estrogen receptive, and environmental estrogens like parabens are known to bind to estrogen receptors. Estrogen-dependent cancers, such as breast cancer, are known to be highly responsive to estrogens for growth. Even more disturbing is the increase in numbers of young girls developing breast cancer. Although many factors such as radiation, alcohol, smoking and diet, add to the risk of developing breast cancer, the predominant influencing factor has been identified as the exposure to estrogens throughout an individual's lifetime 9.

The breast is under hormonal control and a fine balance of hormones is what allows the cell to cell communication. Interaction between these cells and the surrounding fluid of the breast tissue is what controls differentiation and growth of the breast 9. If there is a disruption of those hormones, i.e. through the use of synthetic chemicals, the balance of hormonal control is thrown and the cells do not function normally which may lead to breast cancer. In support of this clinical studies show that estrogen has the capacity to drive breast tumours to grow in laboratory studies. Animal experimental studies have also shown the role of estrogen on the growth of breast cancer cells 9. While chemicals which mimic estrogen have been shown to promote and stimulate the proliferation of breast cancer cells 2,10,11, and activate other processes involved in breast cancer 2,11,12. Recent studies have also shown other factors can dramatically increase the the toxicity of Xenoestrogens and studies of individual estrogens may seriously underestimate their growth and spreading effects in breast tissue cells and their potency to promote breast cancer, particularly at lower doses 13.

Although the vast majority of studies on breast cancer are aimed towards women, men can also suffer from the disease, indicating that they have similar risk factors, with one case in a hundred diagnosed breast cancers being a male 14. Although this number is relatively small, the rate of incidence has increased by 25% in 25 years.

Sperm count of the average male in the US or Europe has been found to be declining continuously over the past four decades, dierectly linked with environmental estrogen exposure, and today it is less than 50% of what it was forty years ago15,16. One result of this lower count is the increased rate of male infertility; which is also the single most common cause of infertility. The rate of infertility has quadrupled in the past forty years, from 4% in 1965 to at least 16% today 15.

Other conditions including undescended testes caused by prenatal estrogen exposure to environmental estrogens have also been found in studies on mice and it has been suggested undescended testes increases the rate of testicular cancer 17. The incidence of testicular cancer, namely affecting males between the ages of 20 to 30, has also seen an increase worldwide. Studies have found strong links with exposure to excessive levels of estrogen with hypospadias (abnormal congenital opening of male urethra upon under surface of the penis) 18,19, lower libido 19, congenital anomalies, cryptorchidism and testicular cancer 20,21,22.

Environmental estrogens have also been linked to early puberty in girls and increasing number of girls experiencing precocious puberty in recent years 15. A study in the United States of 17, 000 girls indicated that 7% of white and 27% of black girls exhibited physical signs of puberty by age seven, and for girls aged 10 the percentages increased to 68 and 95 respectively 16. This trend for earlier puberty has been found to be widespread, with similar cases found in the United Kingdom, Canada and New Zealand (Trankina, M. V L., 2001).

Environmental estrogens are also suspected of disrupting thyroid functioning, sexual differentiation of the brain in foetal development and cognitive motor function 23. It is also believed that high levels of environmental estrogen exposure results in lower birth weights, smaller head circumferences, poorer neuromuscular maturity and visual recognition, delays in psychomotor development, short term memory problems, and growth retardation in newborn babies 24.

Prenatal exposure to environmental estrogens also poses a serious health risks to developing fetus and children as evidence of adverse effect on birth outcomes, childhood obesity, and intellectual disability are increasing 25. The placental barrier has been shown to allow these chemicals to cross as many of them have been measured in human fetal cord blood and tissue. More importantly, because organogenesis begins at the time when the fetus is solely dependent on maternal supply, early life exposure to environmental estrogens may lead to adverse short or long term health outcomes due to fetal reprogramming 26.

From testing on animals it has further been proposed that excessive estrogen levels could cause anxious behaviour 27,28, altered fecundency 29, reduced penis size 30 and increased embryo mortality 24. Environmental estrogens are not only capable of binding to estrogen receptors on cell membranes but are also able to bind to neurotransmitters such as epinephrine, neuroepinophrine and dopamine enabling estrogens to influence the body's central nervous system (CNS) 31. Environmental estrogens have also been shown to effect the body’s immune system 30. A large number of studies have also environmental estrogens to contributing to obesity and diabetes, independent of poor diet and physical inactivity; such chemicals including ingredients found in personal care products and cosmetics such as phthalates and phenols 32,33.

More recently studies have found effects of direct exposure to products instead of just individual chemicals. Extensive observational studies have indicated a relationship between certain hair product use and hormonally imbalances including early menache (puberty) 34,35 and uterine fibroids  36 as well as enlargement of breast tissue in boys and men 37.

 

However, estrogenic (or anti-estrogenic) effects of the personal care products as commercial mixtures have rarely ever been evaluated. In a study of eight commonly used hair and skin products four of the eight personal care products tested (Oil Hair Lotion, Extra-dry Skin Lotion, Intensive Skin Lotion and Petroleum Jelly demonstrated detectable estrogenic activity 38. The estrogenic activity of these products was not predictable by examining their listed ingredients. However, perhaps the most surprising finding about any one product was the estrogenic activity of SP4 (Petroleum Jelly). Petroleum jelly products are also often used on infants as low-cost therapies for common problems such as diaper rash and is manufactured by refinement of the crude petroleum product. While other studies have shown that hair oil use as a child was significantly associated with earlier menarche and hair relaxer use and uterine fibroids among participants in the 36. A third study found an elevated incidence of endometriosis and use of personal care products containing benzophenone-type UV filters 39.

 

Fortunately, studies have also shown it is relatively easy to reduce exposure by reducing personal care use or using safer products. In one study of around 100 girls they replaced their personal care products with safer alternatives for 3 days. The replacement products were chosen on the basis of whether their ingredient lists included triclosan, benzophenone-3, or parabens. Phthalates are not listed on ingredient lists, but they are often found in scented products. So the researchers avoided products that listed “fragrance” as an ingredient unless they were specifically labeled as phthalate free.  More than 90% of the participants had detectible levels of phthalates, parabens, and benzophenone-3 before they started using the replacement products. After using the alternative products for 3 days urinary concentrations of methyl and propyl paraben decreased by 43.9% and 45.4%, respectively, mono-ethyl phthalate decreased by 27.4%, and triclosan decreased by 35.7%. However, there were increases in concentrations of butyl and ethyl paraben, which were detected in about half the girls. These chemicals might have been unintentional contaminants or unlabeled ingredients in replacement products, which they acknowledge they were unable to ensure were paraben free 40.

 

 

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  39. Kunisue T, et al. 2012
  40. Harley KG, et al. 2016

 

 

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Deadly deodorants

Deadly deodorants

In November 2008, a 12 year old boy, Daniel Hurley collapsed and died in his bathroom 'after using too much deodorant'. The hearing into his death found that “he was overcome by solvents in the Lynx Vice spray”. Unfortunately there were no repercussions for the company as the warnings are spelt out on the can. Despite the warning being there, my own research shows that around 1% of people actually read and understand the labels. However, this is not the first, nor is it the last. On July 12 1998, 10 years earlier a young boy in the UK, this time 16 years old who had an obsession with smelling nice died after months of spraying his entire body with deodorant. Jonathon Campbell had 10 times the lethal dose of propane and butane in his blood. While these are tragic outcomes, the real problems lies in the millions of kids (and adults) around the world who are slowly poisoning themselves. The warning signs on most cans reads something like “deliberately concentrating may be harmful or fatal” or for cans sold to kids “must be used in the presence of adults” and the company has no other responsibility to your health than these labels. If people really knew what was in these cans and read these labels closely I am sure they would have second thoughts about using them and giving them to their kids. Unfortunately, the ingredients are not listed and the warning is all in the small print on the back.

The problem with deodorants and antiperspirants is three fold. First the propellant gases like propane and butane are toxic and were implicated in the deaths of both boys. This associated with the fact that they are sprayed upward towards the armpit and headspace means you can’t help but breathe them in. The second is the long list of toxic ingredients used in the deodorants and antiperspirants which you don’t know about and which are absorbed through the skin and thirdly the blocking of our pores by the antiperspirants.

To highlight where the problem starts antiperspirants and deodorants are among the top six products causing adverse skin reactions, including itching, burning, dryness, irritant dermatitis and allergic contact dermatitis. They have become one of the most frequently purchased products worldwide, surpassed in market share only by soaps and hair care products. Unfortunately, they are also one of the most widely marketed products constantly playing on kids’ emotional health, sex and relationships to sell their toxic products.

Deodorants act to reduce, cover up, or eliminate the odour that develops when bacteria break down perspiration. This is achieved by the use of anti-microbial agents and fragrances. Antiperspirants are distinguished from deodorants by the presence of sweat retarding agents. These agents are based on aluminium complexes and may include aluminium chlorohydrate (ACH), aluminium zirconium chlorohydrate glycine complexes (AZAP) or aluminium zirconium tetrachlorohydroxy glycine. While the connection between aluminium in antiperspirants and Alzheimer's disease and epilepsy continue to be explored and debated they seem highly unlikely. Other problems such as a link with breast cancer are much more likely. The action of these chemicals limits the levels of perspiration produced in the underarm and other areas, by slowing the action of the sweat glands. Sweat production is reduced due to the fact that the chemicals produce an obstructive hydroxide gel inside the sweat gland ducts, limiting the amount of perspiration that can be excreted. However, we were meant to sweat. Sweating provides a valuable service to our body by eliminating waste products, and cooling down the body. As a result antiperspirants may lead to a build up of toxins in this area just near the breast.

Antiperspirant and deodorant ingredients include anti-microbials such as chlorhexidine d-1-gluconate and triclosan, odour eliminators such as zinc ricitioleate and various perfumes. Other ingredients which may cause contact allergies include formaldehyde, atranorm, evernic acid, fumarprotocetraric acid, cetalkonium chloride, fenticlor, gluteraldehyde, zirconium and dibutyl phthalate. Many of the same chemicals you would find in toilet deodorants. Starting to sound a bit smelly isn’t it. Formaldehyde is a skin irritant and thought to be carcinogenic, and phthalates are suspected of producing endocrine (hormone)‑disrupting effects as they are able to mimic the action of oestrogen and upset our hormone balance. In one study diethyl phthalate, which is a solvent, was detected in 2 out of 8 deodorants. The breast, as a result, is also exposed to a range of these oestrogenic chemicals applied to the underarm and breast area. These cosmetics are left on the skin in the appropriate area, allowing a more direct dermal absorption route for breast exposure to oestrogenic chemicals and allowing absorbed chemicals to escape systemic metabolism. It is also worth noting that the large increase in breast cancer over the last 30 years has been a result of an increase in oestrogen receptive cancers.

Research has shown that repeated application of deodorants permeate the skin resulting in accumulation of some of these chemicals. According to one study butyl paraben was systemically absorbed, metabolized and excreted in urine following application to the skin in a cream preparation. The study conducted over 2 weeks showed concentration peaked in urine 8-12 hours after application.  Isn’t it interesting to know that the chemicals you put on the outside of your body get in?

Then the problem is exacerbated even more when they are used in spray containers that we direct towards our face. If your lungs are a uniquely designed sponge for air, they are also a sponge for the contaminants that manage to evade all of your respiratory system’s defenses. All the ingredients and the propellants are rapidly absorbed into the body and detectable throughout the body within minutes to hours.

The safer option is to use roll on deodorant. Unfortunately, it does not look as sexy in the advertisements, but it is much safer. The next step is then to move toward natural products and organic when you can. We have evolved with natural plant products over millions of years and as a general rule they are much safer than synthetic products manufactured from petrol. I also think it is about time we stop overselling these products and teaching kids that too much fragrance can be toxic… and who would want to smell like a toilet block anyway?

 

 


 

 

 

 

 

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Endocrine-disrupting chemicals found in common household products cost hundreds of billions of dollars in health

Endocrine-disrupting chemicals found in common household products cost hundreds of billions of dollars in health

Endocrine-disrupting chemicals (EDCs) found in common household products and our environment cost the USA economy $340 billion in added health costs and the European economy $217 billion.

Endocrine-disrupting chemicals (EDCs) contribute to disease and dysfunction and incur high associated costs. The disease costs of EDCs were much higher in the USA ($340 billion) than in Europe [( $217 billion). The difference was driven mainly by intelligence quotient (IQ) points loss and intellectual disability due to polybrominated diphenyl ethers (11 million IQ points lost and 43 000 cases costing $266 billion in the USA vs 873 000 IQ points lost and 3290 cases costing $12·6 billion in the European Union).

With annual costs being so high the researchers suggest the need for improved screening for chemical disruption to endocrine systems and proactive prevention. Exposure to chemicals in pesticides, toys, makeup, food packaging and detergents costs the U.S. more than $340 billion annually due to health care costs and lost wages. The chemicals, known as endocrine disruptors, impact how human hormones function and have been linked to a variety of health problems such as impaired brain development, lower IQs, behavior problems, infertility, birth defects, obesity and diabetes.

The researchers also looked at common chemicals such as bisphenol-A (BPA), used in polycarbonate plastics, food tin cans and receipts; and phthalates, found in food containers and cosmetics.

The authors of the study said their prediction is that the calculated costs to society will increase substantially once we get better documentation on ..additional substances and additional adverse effects.

 

http://www.thelancet.com/journals/landia/article/PIIS2213-8587(16)30275-3/fulltext

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Study shows how to reduce exposure to Personal care toxins in adolescent girls

Study shows how to reduce exposure to Personal care toxins in adolescent girls

A study released this week in the journal Environmental Health Perspectives showed that using personal care products without toxic endocrine (hormone) disrupting chemicals (EDC’s) for 3 days dramatically reduces exposure levels in girls. These chemicals have been linked with many health disorders including a recent findings showing a very strong link with breast cancer in human and animal studies. Malignant breast tumors are the leading cause of cancer in women worldwide in terms of incidence and mortality.

Cosmetics, fragrances, and other personal care products are a possible source of human exposure to potentially endocrine-disrupting chemicals, such as phthalates, parabens, and phenols especially for woman and adolescent girls. Women are the primary consumers of many personal care products, they are disproportionately exposed to these chemicals. Adolescent girls may be at particular risk of exposure through this route. For example, one small study found that the average adult woman uses approximately 12 individual personal care products each day, whereas the average teenage girl uses 17. Personal care products are a source of exposure to potentially endocrine-disrupting chemicals such as phthalates, parabens, triclosan, and benzophenone-3 (BP-3) for adolescent girls.

Personal care product use is widespread, and human exposure to these chemicals is nearly ubiquitous, with mono-ester phthalate metabolites of DEP, DnBP, and DiBP detected in the urine of more than 96% of Americans. Methyl and propyl parabens were found in more than 90% of individuals, BP-3 in 97%, and triclosan in 75%

The three phthalates most commonly used in personal care products are diethyl phthalate (DEP), which is found in scented products, including perfumes, deodorants, soaps, and shampoo; and di-n-butyl phthalate (DnBP) and di-isobutyl phthalate (DiBP), which are used in nail polish and cosmetics. The parabens commonly used in personal care products include methyl, ethyl, butyl, and propyl paraben, which are used as preservatives and antibacterial agents in cosmetics. Two phenols are also commonly used in personal care products. Triclosan is an antimicrobial compound used in liquid soaps, acne cream, deodorants, shaving cream, and certain toothpastes. Benzophenone-3 (BP-3), also known as oxybenzone, is used in sunscreens, lip balm, and other sun protection products.

In a study of 100 Latina girls using personal care products that did not contain these chemicals for just 3 days significantly lowered their urinary concentrations of the chemicals. Urine samples were analyzed for phthalate metabolites, parabens, triclosan, and BP-3. The study found most of the EDC’s were significantly lowered after 3 days but not all. Urinary concentrations of mono-ethyl phthalate (MEP) decreased by 27.4% on average over the 3-day intervention but no significant changes were seen in urinary concentrations of mono-n-butyl phthalate (MnBP) and mono-isobutyl phthalate (MiBP). Methyl and propyl paraben concentrations decreased by 43.9% and 45.4% respectively. Unexpectedly, concentrations of ethyl and butyl paraben concentrations increased, although concentrations were low overall and not detected in almost half the samples. Triclosan concentrations decreased by 35.7% and BP-3 concentrations decreased by 36.0%.

This study demonstrates that choosing personal care products that are labeled to be free of phthalates, parabens, triclosan, and BP-3, can reduce personal exposure to possible endocrine-disrupting chemicals.

Source

Kim G. Harley,et al 2016. Environ Health Perspect; DOI:10.1289/ehp.1510514. Reducing Phthalate, Paraben, and Phenol Exposure from Personal Care Products in Adolescent Girls: Findings from the HERMOSA Intervention Study.

http://ehp.niehs.nih.gov/EHP157/

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