Dr Dingle's Blog / probiotic
Treatments for obesity have been shown to reduce pain secondary to weight loss. Intestinal microbiota has been shown to influence obesity and pain sensitivity.
Physiological pain plays a life-essential protective role, while acute or chronic pathological pain indicates a medical problem that needs treatment and imposes a medical challenge. Neurotransmitters, immune cells, and hormones have been demonstrated to contribute in pathogenesis of chronic pain.
Pain threshold is influenced by several factors, including obesity, which alters adipose tissue metabolic and endocrine functions leading to alterations in systemic physiology including an increased release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity associated complications. Studies have demonstrated that obese humans and rats are more sensitive to pain stimuli than normal weighted ones.
Previous studies have demonstrated a relationship between intestinal microbiota and diseases including pain disorders with probiotics having a positive effect.
In this study the mice taking probiotics had a significantly lower sensitivity to mechanical stimulation compared to their corresponding control. The results of this study suggest a protective effect of probiotics on nociception circuits, which propose a direct result of the weight reduction or an indirect result of anti-inflammatory properties of the probiotics.
Potential Nociceptive Regulatory Effect of Probiotic Lactobacillus rhamnosus PB01 (DSM 14870) on Mechanical Sensitivity in Diet-Induced Obesity Model
Numerous studies have now shown the benefits of probiotics and prebiotics in reducing inflammation and oxidation. A recent meta-analysis indicated a significant reduction in serum CRP following probiotics. Studies suggest the consumption of probiotic yogurt containing L. acidophilus and Bifidobacterium animalis in pregnant women for nine weeks led to a reduction in inflammation (CRP) as it did for colorectal cancer, autoimmune disease, and chronic kidney disease. A number of studies have shown that prebiotics can benefit the elderly who suffer from chronic inflammation by improving their gut microbiota and immune function, ultimately reducing inflammation and oxidation. An 8 g daily prebiotic mixture given for three weeks to elderly subjects reduced inflammation (IL-6) improved T cell counts –immune function.
The anti-inflammatory and antioxidant properties of probiotics are thought to act by reducing gut inflammation. Good gut bacteria produce short chain fatty acids (SCFAs) following the fermentation of soluble fibre by gut bacteria like butyrate, propionate and acetate, which are anti-inflammatory. The probiotics, Lactobacillus plantarum, isolated from Chinese traditional Tibetan kefir grains, had strong reducing capacities, lipid peroxidation inhibition capacities, iron-chelating abilities, various free radical scavenging capacities and potent antioxidant activity.
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Since 2006 there has been a large body of scientific evidence showing the gut microbiota is interlinked with obesity and other metabolic conditions including type 2 diabetes. Probiotics are live micro-organisms that confer health benefits to the host and prebiotics are fibers that selectively improve the growth of beneficial gut microbes. Previous animal studies have shown probiotics prevented weight gain, improved insulin sensitivity, as well as reduced endotoxemia and tissue inflammation
In a study of 225 healthy volunteers randomized into four groups those taking the prebiotic with the probiotic or the probiotic alone improved weight. The prebiotic with probiotic group showed a − 4.5% or 1.4 kg difference to the Placebo group, and the probiotic group alone had a − 3.0 reduction in body fat. Changes in fat mass were most pronounced in the abdominal region, and were reflected by similar changes in waist circumference. Both groups also saw a reduction in inflammation.
This clinical trial demonstrates that a probiotic product with or without dietary fiber controls body fat mass and also reduced waist circumference and food intake.