Dr Dingle's Blog / mycobiome

Controlling candida

Controlling candida

Candida has a high degree of resistance to many available drugs. In the case of candida it is not just candia on its own but the potential associations it has with other opportunistic species and how they work together to protect each other with a resilient biofilm. The most important feature of biofilm growth is the high resistance to antimicrobial agents. To deal with this the best options are to use multiple strategies.

The best approach is to eat more of the functional foods, herbs and spices on a daily basis which help rebalance the gut microbiome and eliminate the opportunistic specises like Candida. Aloe vera in both its crude and extract form has been shown to have positive antimicrobial effects especially against Candida species. Aloe has also been shown to be effective against some pathogenic specis including Salmonella gallinarum. One study investigated the effect of Aloe when consumed orally in patient suffering from an inflammatory bowels disease given at the rate of two ounces three times daily for a week was able to rebalance the regulating gastrointestinal motility and decrease stool transit leading to curing diarrhea.

Coconut oil and its constituent fatty acids have potent antifungal activity and have been shown to both inhibit the growth of and kill C. albicans in vitro (Kabara et al 1972). In mice, coconut oil effectively reduced colonization of candida across a range of doses (12 to 30%).

Herbs are rich in phytochemical constituents like polyphenols that possess antioxidant, antimicrobial and immunomodulatory properties. A number of natural products have been shown to be effective in controlling fungi growth including curcumin from turmeric. Trumeric, ginger and Xanthorrhizol, isolated from Curcuma xanthorrhiza a cousin of turmeric in the ginger family have been shown to be effective against multiple Candida species and other opportunistic fungi and as a treatment for the treatment of candidiasis. Garlic’s antibacterial activity has been first stated by Louis Pasteur; and there are also reports of its antifungal and antiviral activities.

Other herbs including Berberine has also been shown to have significant antimicrobial activity against bacteria, viruses, protozoa, fungi, and yeasts (Tan et al 2011). As well as extracts from Trigonella foenum-graecum (fenugreek) seeds, Cinnamomum verum (Celyon cinnamon) bark, Carica papaya (papaya) leaves and seeds and sweet basil leaf herbal oils seem to be highly effective anti-Candida choices.

Disturbances of the bacterial community in the GI tract promote C. albicans colonization suggesting that the normal bacterial microbiota of the GI tract have an inhibitory effect against fungal colonisation and invasion. Lactobacillus spp. appear inhibit the growth and virulence of C. albicans by the production of hydrogen peroxide and organic acids, but not fully eradicate them. They may also exert some effect on the Candida through the immune system. Similar results have also been shown for supplementation with some fungal probiotics, such as Saccharomyces boulardii which compete with Candida species for gut space.

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Mothers milk mycobiome (fungi) - not microbiome

Mothers milk mycobiome (fungi) - not microbiome

Compared to bacterial communities, the human gut mycobiome (fungi) is low in diversity and dominated by yeast including Saccharomyces, Malassezia, and Candida.Studies show they also vary substantially over time and even mice in the same or different cages in the same facility receiving the same feed and treatment also varied in their dominant fungal lineage. Similar results have been shown with humans.

During the last years, human breast milk has been documented as a potential source of bacteria for the newborn. Recently, we have reported the presence of fungi in breast milk from healthy mothers. It is well-known that environmental and perinatal factors could affect milk bacteria; however, the impact on milk fungi is still unknown.

Recent studies report the presence of fungal species in breast milk of healthy mothers, suggesting a potential role on infant mycobiome development. In the present work, we aimed to determine whether the healthy human breast milk mycobiota is influenced by geographical location and mode of delivery, as well as investigate its interaction with bacterial profiles in the same samples. A total of 80 mature breast milk samples from 4 different countries

This study found fungal communities (mycobiota) in breast milk samples across different geographic locations and the influence of mode of delivery. They identified a core of four genera shared across locations, constituted by Malassezia, Davidiella, Sistotrema and Penicillium which have been reported to be present in the infant gut. Our data confirm the presence of fungi in breastmilk across continents and support the potential role of breast milk on the initial seeding of fungal species to the infant gut.

Analysis of bacteria and fungi showed complex interactions that were influenced by geographical location, mode of delivery, maternal age and pre-gestational Body Mass Index. The presence of a breast milk mycobiome was confirmed in all the samples analysed, regardless of the geographic origin.

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Mothers milk mycobiome (fungi) - not microbiome

Mothers milk mycobiome (fungi) - not microbiome

Compared to bacterial communities, the human gut mycobiome (fungi) is low in diversity and dominated by yeast including Saccharomyces, Malassezia, and Candida.Studies show they also vary substantially over time and even mice in the same or different cages in the same facility receiving the same feed and treatment also varied in their dominant fungal lineage. Similar results have been shown with humans.

During the last years, human breast milk has been documented as a potential source of bacteria for the newborn. Recently, we have reported the presence of fungi in breast milk from healthy mothers. It is well-known that environmental and perinatal factors could affect milk bacteria; however, the impact on milk fungi is still unknown.

Recent studies report the presence of fungal species in breast milk of healthy mothers, suggesting a potential role on infant mycobiome development. In the present work, we aimed to determine whether the healthy human breast milk mycobiota is influenced by geographical location and mode of delivery, as well as investigate its interaction with bacterial profiles in the same samples. A total of 80 mature breast milk samples from 4 different countries

This study found fungal communities (mycobiota) in breast milk samples across different geographic locations and the influence of mode of delivery. They identified a core of four genera shared across locations, constituted by Malassezia, Davidiella, Sistotrema and Penicillium which have been reported to be present in the infant gut. Our data confirm the presence of fungi in breastmilk across continents and support the potential role of breast milk on the initial seeding of fungal species to the infant gut.

Analysis of bacteria and fungi showed complex interactions that were influenced by geographical location, mode of delivery, maternal age and pre-gestational Body Mass Index. The presence of a breast milk mycobiome was confirmed in all the samples analysed, regardless of the geographic origin.

Read more →