In the past few decades, synthetic fragrance compounds have become ubiquitous components of personal care and household cleaning products. Overwhelming consumerism trends have led to the excess usage of these chemicals. It has been observed that this fragrance-laden unhealthy lifestyle runs parallel with the unprecedented rates of diabetes, cancer, neural ailments, teratogenicity, and transgender instances. The link between fragrances as and the health outcomes can remain latent for decades.
The adverse effects of the fragrance constituents as phthalates, paraben, glutaraldehyde, hydroperoxides, oil of turpentine, metals, nitro musks, and essential oils, among others, are being identified. The endocrine-immune-neural axis pathways of these chemicals are being proven. Despite this a majority of the vulnerable populations are unaware and unmotivated to avoid these 'slow poisons'. Possible mechanism for thier action include acidosis, aromatase upregulation, estrogen hyperproduction and inflammation.
Fragrance compounds share structural similarity with carcinogenic environmental hydrocarbons are able to mimic estrogen, the powerful signaling hormone, which underlies the majority of morbidities.
Studies have found around 15 chemicals that are positively associated with younger menopausal age and the two major culprits were phthalates found in everyday makeup and personal care products. Of the 13 chemicals the strongest influence was 3.8 years younger for mono-(2-ethyl-5-hydroxyhexyl)phthalate, compared with less-exposed women. Another study found a link between early menopause and elevated serum levels of perfluorooctanoic acid (PFOA), or teflon an industrial chemical used in several nonstick and stain-repellant applications. Manufactured for decades, PFOA is now widespread in the biosphere, and most people have some in their bodies. The chemical accumulates in blood, so women of reproductive age will eliminate some of it when they menstruate. This result was also found in two prior studies of polyfluoroalkyl chemicals (PFCs) including PFOA.