Dr Dingle's Blog / herbs

Glucosamine is good for the heart not just arthritis

Glucosamine is good for the heart not just arthritis

Glucosamine supplements for arthritis also lowers the risk of cardiovascular disease.
Joint pain is reported by 32% of U.S. adults, and increases with age reaching 50% prevalence among the elderly. Joint pain is slightly more prevalent among women (33%) than men (31%). The knee is the most common site of joint pain regardless of age or gender. Joint pain is associated with substantial activity limitation, work disability, and reduced quality of life. Adults with joint pain are more likely to report arthritis-attributable activity limitations, fair or poor health, inability to work, low sleep duration and psychological distress. Predictors of knee pain include older age, weight gain and obesity, and previous knee injury, with the combination of weight loss with exercise a well-recognized intervention to alleviate symptoms and improve function.
 
Glucosamine is a non-vitamin, non-mineral supplement widely used to relieve osteoarthritis and joint pain. In countries like the United States and Australia, it is a popular dietary supplement and approximately 20% of adults consume it daily.
In addition to its benefits for osteoarthritis and joint pain emerging evidence from epidemiological studies suggests that glucosamine could have a role in preventing cardiovascular disease (CVD) and reducing mortality. A previous animal study reported that glucosamine extended life span by mimicking a low carbohydrate diet,
Other animal studies have reported that the anti-inflammatory properties of glucosamine might have a preventive role in atherosclerosis development.
The latest findings suggest that glucosamine could help prevent coronary heart disease and stroke. The study found a 15% decrease in total CVD events, 22% reduction in CVD death, 18% decrease in coronary heart disease, and a 9% reduction in stroke.
Interestingly people with osteoarthritis (inflammation) are at increased rick of CVD.. While clearly more research needs to be done on this it outperforms most drugs and has only positive side effects.
 
Glucosamine compounds have also been reported to have several other beneficial effects on the skin or skin cells. Because of its stimulation of hyaluronic acid synthesis, glucosamine has been shown to accelerate wound healing, improve skin hydration, and decrease wrinkles. In addition, as an inhibitor of tyrosinase activation, it inhibits melanin production and is useful in treatment of disorders of hyperpigmentation. Glucosamine also has both anti-inflammatory
Based on other observations, glucosamine has been suggested for additional clinical uses, including treatment of inflammatory bowel disease, migraine headaches, and viral infections.
 
https://www.bmj.com/content/365/bmj.l1628
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Controlling candida

Controlling candida

Candida has a high degree of resistance to many available drugs. In the case of candida it is not just candia on its own but the potential associations it has with other opportunistic species and how they work together to protect each other with a resilient biofilm. The most important feature of biofilm growth is the high resistance to antimicrobial agents. To deal with this the best options are to use multiple strategies.

The best approach is to eat more of the functional foods, herbs and spices on a daily basis which help rebalance the gut microbiome and eliminate the opportunistic specises like Candida. Aloe vera in both its crude and extract form has been shown to have positive antimicrobial effects especially against Candida species. Aloe has also been shown to be effective against some pathogenic specis including Salmonella gallinarum. One study investigated the effect of Aloe when consumed orally in patient suffering from an inflammatory bowels disease given at the rate of two ounces three times daily for a week was able to rebalance the regulating gastrointestinal motility and decrease stool transit leading to curing diarrhea.

Coconut oil and its constituent fatty acids have potent antifungal activity and have been shown to both inhibit the growth of and kill C. albicans in vitro (Kabara et al 1972). In mice, coconut oil effectively reduced colonization of candida across a range of doses (12 to 30%).

Herbs are rich in phytochemical constituents like polyphenols that possess antioxidant, antimicrobial and immunomodulatory properties. A number of natural products have been shown to be effective in controlling fungi growth including curcumin from turmeric. Trumeric, ginger and Xanthorrhizol, isolated from Curcuma xanthorrhiza a cousin of turmeric in the ginger family have been shown to be effective against multiple Candida species and other opportunistic fungi and as a treatment for the treatment of candidiasis. Garlic’s antibacterial activity has been first stated by Louis Pasteur; and there are also reports of its antifungal and antiviral activities.

Other herbs including Berberine has also been shown to have significant antimicrobial activity against bacteria, viruses, protozoa, fungi, and yeasts (Tan et al 2011). As well as extracts from Trigonella foenum-graecum (fenugreek) seeds, Cinnamomum verum (Celyon cinnamon) bark, Carica papaya (papaya) leaves and seeds and sweet basil leaf herbal oils seem to be highly effective anti-Candida choices.

Disturbances of the bacterial community in the GI tract promote C. albicans colonization suggesting that the normal bacterial microbiota of the GI tract have an inhibitory effect against fungal colonisation and invasion. Lactobacillus spp. appear inhibit the growth and virulence of C. albicans by the production of hydrogen peroxide and organic acids, but not fully eradicate them. They may also exert some effect on the Candida through the immune system. Similar results have also been shown for supplementation with some fungal probiotics, such as Saccharomyces boulardii which compete with Candida species for gut space.

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