Dr Dingle's Blog / healthy ageing

Glucosamine is good for the heart not just arthritis

Glucosamine is good for the heart not just arthritis

Glucosamine supplements for arthritis also lowers the risk of cardiovascular disease.
Joint pain is reported by 32% of U.S. adults, and increases with age reaching 50% prevalence among the elderly. Joint pain is slightly more prevalent among women (33%) than men (31%). The knee is the most common site of joint pain regardless of age or gender. Joint pain is associated with substantial activity limitation, work disability, and reduced quality of life. Adults with joint pain are more likely to report arthritis-attributable activity limitations, fair or poor health, inability to work, low sleep duration and psychological distress. Predictors of knee pain include older age, weight gain and obesity, and previous knee injury, with the combination of weight loss with exercise a well-recognized intervention to alleviate symptoms and improve function.
 
Glucosamine is a non-vitamin, non-mineral supplement widely used to relieve osteoarthritis and joint pain. In countries like the United States and Australia, it is a popular dietary supplement and approximately 20% of adults consume it daily.
In addition to its benefits for osteoarthritis and joint pain emerging evidence from epidemiological studies suggests that glucosamine could have a role in preventing cardiovascular disease (CVD) and reducing mortality. A previous animal study reported that glucosamine extended life span by mimicking a low carbohydrate diet,
Other animal studies have reported that the anti-inflammatory properties of glucosamine might have a preventive role in atherosclerosis development.
The latest findings suggest that glucosamine could help prevent coronary heart disease and stroke. The study found a 15% decrease in total CVD events, 22% reduction in CVD death, 18% decrease in coronary heart disease, and a 9% reduction in stroke.
Interestingly people with osteoarthritis (inflammation) are at increased rick of CVD.. While clearly more research needs to be done on this it outperforms most drugs and has only positive side effects.
 
Glucosamine compounds have also been reported to have several other beneficial effects on the skin or skin cells. Because of its stimulation of hyaluronic acid synthesis, glucosamine has been shown to accelerate wound healing, improve skin hydration, and decrease wrinkles. In addition, as an inhibitor of tyrosinase activation, it inhibits melanin production and is useful in treatment of disorders of hyperpigmentation. Glucosamine also has both anti-inflammatory
Based on other observations, glucosamine has been suggested for additional clinical uses, including treatment of inflammatory bowel disease, migraine headaches, and viral infections.
 
https://www.bmj.com/content/365/bmj.l1628
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The healing power of raw cabbage

The healing power of raw cabbage

Another reason to add some of the cabbage family to your daily diet, preferably raw is because of their gut healing properties and how they promote gut health through the gut microbiome. The Brassica family including cabbage, broccoli, brussel sprouts, kale, arugula (rocket), bok choy, cauliflower, collard greens, radish, turnip and others have been recognized for their gut healing and gut health properties for hundreds of years and modern epidemiologic studies have shown a frequent consumption of cruciferous vegetables is associated with lower risk of cancer, especially cancers of the digestive tract, bladder, breast, prostate, and lung. However, only now are we recognizing that many of these benefits are mediated through the microbiome and that their frequent consumption alters the composition of the microbiome.

Cruciferous vegetables are a rich source of glucosinolates a precursor to the Isothiocyanates (ITC), which exhibit powerful biological functions in fighting cancers, cardiovascular, neurodegenerative diseases and gut healing. The Isothiocyanates are a by product of specific plant enzymes (myrosinase) active during chewing or crushing when broccoli is consumed raw or lightly steamed, however, like all enzymes myrosinase is deactivated by cooking and ingestion of cooked broccoli typically provides only about one tenth the amount of isothiocyanates as that from raw broccoli. So to maximize the gut healing, gut health and overall benefits of these foods they are best eaten raw or just lightly steamed.

Instead when cooked cruciferous vegetables are consumed, gut bacteria are mainly responsible for ITC production in the gut. This is highlighted after taking oral antibiotics, the ITCs availability and uptake decreases after eating cooked cruciferous vegetable. It also appears that there is considerable difference in the ability of individuals, due to individual differences in gut microbial community, to produce the isothiocyanates. Although, the gut communitys ability is altered over just 4 days. In one study feeding raw or cooked broccoli for four days or longer both changed the microbiota composition and caused a greater production of isothiocyanates. Interestingly, a three-day withdrawal from broccoli reversed the increased microbial metabolites suggesting that the microbiota requires four or more days of broccoli consumption and is reversible.

The lactic acid bacteria appear to have myrosinase-like activity and the fermented Brassica food products, such as sauerkraut and kimchi, are particularly rich in Lactobacillus, and a diet rich in Brassica may promote Lactobacillus growth in the colon.

 

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Lifestyle changes can add 14 years or more to your life. Not drugs

Lifestyle changes can add 14 years or more to your life. Not drugs

Americans have a shorter life expectancy compared with residents of almost all other high-income countries despite the fact that they spend more money on their health care (pharmaceuticals) than any other country.

In this study adopting five major health initiatives—regular exercise, a healthy diet, moderate drinking, not getting overweight or obese and not smoking can extend your life by around 14 years. Each of the healthy lifestyles lowers your chances of getting one of the chronic health problems, such as heart disease and cancer.

This study shows that healthier lifestyles would reduce the rate of premature death from heart disease by 75 per cent, and cancer deaths by 50 per cent, the researchers estimate.

This study yet again highlights the need to focus on lifestyle and diet and not on the pharmaceutical model of health. While there is consistent evidence showing their role in extending life and the quality of life there is virtually no evidence to show pharmaceuticals extend life. However roughly 50% of the lobbyists in the capitals are from pharmaceutical companies.

https://www.drdingle.com/collections/book-sales/products/overcoming-illness-pre-order

Source

Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population.

http://circ.ahajournals.org/content/early/2018/04/25/CIRCULATIONAHA.117.032047

 

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