Dr Dingle's Blog / dietary inflammation index
We now know the gut is the cornerstone of health and inflammation in the body. The first theory to explain the link between the gut and inflammation, which underlies all the chronic diseases we suffer from, was put forward in 1907, when Elie Metchnikoff proposed that tissue destruction (disease) and senescence (ageing) throughout the body were consequences of chronic systemic inflammation, which occurred as a result of increased permeability in the colon and the escape of bacteria and their products into the blood. He believed that these bacterial products activated our immune response (macrophages) and that the resulting inflammatory response caused deterioration of surrounding tissues and that this macrophage “intoxification” had systemic effects and led to deterioration of even distant tissues. And he was right.
Over 100 years later a new health paradigm emerging from the research is that there is a common pathway from wellbeing and health to chronic disease ("chronopathy") and even to death, which comprises following steps: 1) unhealthy diet, sedentary and stressed life style and exposure to toxic chemicals;→2) intestinal dysbiosis;→3) alteration of the intestinal mucus layer (especially that of the colon);→4) poisons and bacteria getting into the blood;→6) inflammation;→7) dysfunction of the gut and all the systems that it links into;→8) changes in our gene expression , epigenetics;→9) "chronopathy" and premature death.
Therefore, in order to maintain a good health or to improve or even reverse chronic diseases in a person, the main action is to improve the gut, the intestinal microbiota (eubiosis), most of which is located in the colon. We rely totally on our gut microbiome for our health and they play a pivotal role of intestinal microbiota in human health, disease and, in general, in its wellbeing.
The main implication of this theory is that we should become a sort of gut microbiota farmers, that is, we ought to be more conscious of our intestinal microbiota, take care of it and monitor it permanently. Thus, as part of our good life habits (healthy eating, physical exercise), we need to find out what we can do to improve our gut health.
 Gonzalez-Correa et al., 2017
 Ibid, 2017.
Dr Dingle's WA. Gut Helalng Tour
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Atherosclerotic cardiovascular disease (CVD) such as acute heart atacks and stroke remains the leading cause of death worldwide. Both epidemiological and clinical studies have shown a strong link between inflammation, such as C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, and the risk of cardiovascular events. Studies have also shown a strong link with inflammation and insulin resistance, an important determinant of CVD and diabetes.
So it all comes down to inflammation
In this study they investigated the link between inflammation insulin resistance and fat consumption and found insulin resistance linked with inflammation (hs-CRP and IL-6) and these inflammatory biomarkers were positively associated with saturated fatty acids and negatively associated with unsaturated fatty acids and monounsaturated fats. Dietary components, especially fatty acids, affect the expression and release of inflammatory biomarkers. Polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have a cardioprotective effect by reducing inflammation. Indeed, clinical studies have shown that diets may have effect on inflammatory biomarkers.
What does this mean?
One step to lower you inflammation and risk of CVD the major killer in in the world (and all chronic illness if you read my work) is to increase your omega 3 fatty acid and lower some of your saturated fats. There are many other ways to lower your inflammation and risk of chronic disease including lifestyle and dietary changes.
All chronic illness including cancers, osteoporosis, cardiovascular disease and renal disease and more are linked through inflammation which is described in my latest book "Overcoming Illness". Cardiovascular disease (CVD) is one of the most common causes of morbidity and mortality in different communities accounting for more than 31% or 17.5 million deaths worldwide.
In this study of 454 patients aged 35-80 years a high dietary inflammatory Index (DII- higher inflammation producing in the foods they eat) scores were associated with higher age, higher prevalence of diabetes and myocardial infarction (MI- heart attack) and lower educational attainment. Male patients in top half of DII had significantly higher total cholesterol (TC), triglyceride (TG), albumin, creatinine, BUN and hs-CRP concentrations and lower high density lipoprotein cholesterol (HDL) concentrations compared with male patients in lower half. While in female patients, only lipoprotein (a) concentrations and hematocrit (HCT) percentage in the 4th and 2nd quartile were significantly higher than lower quartiles.
The results clearly show a positive association with the inflammation level in foods and several cardiovascular risk factors. The higher inflammatory potential of diet denoted higher values of serum lipids, CRP and kidney function tests.
Current evidence supports that inflammation is a major driving force in patients with coronary artery disease, underlying the initiation of coronary plaques, their unstable progression, and eventual disruption. The pro-inflammatory nature of the cardiovascular disease can be explained by this fact that almost in all of the atherosclerosis processes inflammatory molecules are involved
Diet and dietary habits play a crucial role in the pathogenesis of cardiovascular disease and dietary habits are potential determinants of the disease severity. The role of dietary factors and nutritional regimens in the prevention of cardiovascular disease (CVD) and its progression has been extensively studied; numerous reports suggested the role of healthy dietary choices and improved life style with higher physical activity level and higher intakes of healthy foods including fruits and vegetables and dietary antioxidants in prevention and treatment of cardiovascular event.
Overcoming Illness is the book that explains all about inflammation and oxidation, their link with chronic illness and how to lower inflammation to improve your health and overcome illness.