Fluoride readily crosses the placenta exposing the developing brain, which is much more susceptible to injury caused by toxicants than is the mature brain, may possibly lead to damage of a permanent nature 4
In a study conducted by Tianjin Medical University in China, a comparison in the Intelligence Quotient (IQ) was measured between 60 children living in a high fluoride area and 58 children living in a low fluoride area. The IQ of the 60 children living in the high fluoride area was lower than that of the 58 children living in the low fluoride area. 21.6% of the children in the high fluoride area were retarded compared to 3.4% of retarded children living in the low fluoride area 5.
In a study at Tokyo University Medical School, water fluoridation was linked to Down syndrome. The study found that - as well as the aging of mothers - the number of excess Down syndrome births caused each year by water fluoridation was estimated to be several thousand cases throughout the world 6.
In the most recent meta analysis of 27 eligible epidemiological studies found that children in high fluoride areas had significantly lower IQ scores than those who lived in low fluoride areas 7. The conclusions of the study “support the possibility of an adverse effect of high fluoride exposure on children’s neurodevelopment.”
Some of the other adverse health effects of fluoride include lowered levels of collagen synthesis, depleted energy reserves and lowered immunity, irritable bowel syndrome,thyroid disorders, Skeletal fluorosis, Osteosarcoma, Osteoporosis and bone fractures as well as Alzheimer's disease.
1 NRC (National Research Council). 2006. Fluoride in drinking water: a scientific review of EPA’s standards. The National Academies Press, Washington, DC
2 Chioca LR, Raupp IM, Da Cunha C, Losso EM, Andreatini R. 2008. Subchronic fluoride intake
induces impairment in habituation and active avoidance tasks in rats. Eur J Pharmocol
3 Mullenix PJ, Denbesten PK, Schunior A, Kernan WJ. 1995. Neurotoxicity of sodium fluoride in rats. Neurotoxicol Terator 17:169-177.
4 U.S. EPA. 2011. EPA and HHS announce new scientific assessments and actions on fluoride/agencies working together to maintain benefits of preventing tooth decay while preventing excessive exposure
5 Lu, Y; Sun, ZR; Wu, LN; Wang, X; Lu, W; Liu SS (May 2000) “Effect of High Fluoride Water on Intelligence in Children” , Fluoride (Journal) Volume 33, No 2, pp 74 – 78.
6 Takahashi, K (May 1998) “Fluoride-Linked Down syndrome Births” , Fluoride (Journal) Volume 31, No 2, pp 61 – 73.
7 Choi AL, Sun G, Zhang Y, Grandjean P 2012. Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis. Environ Health Perspect :-. http://dx.doi.org/10.1289/ehp.1104912